is cbd oil good for alzheimer’s disease

Best CBD Oil for Alzheimer’s

Are you looking for an alternative solution to manage Alzheimer’s disease? Below are some CBD product recommendations you may consider to help you with this condition.

Spruce 750mg Lab Grade CBD Oil
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

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Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

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Best High Potency

Spruce 2400mg Lab Grade CBD Oil
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

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Avida Full Spectrum CBD Oil Tincture 500mg
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

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cbdMD CBD Oil Tincture Natural 1500mg
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use

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CBDistillery THC Free CBD Oil Tinctures
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

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Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

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Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

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Best Flavor Range

Hemp Bombs 750mg CBD Oil
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

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Best CBD Oil for Alzheimer’s 2022

    Editor’s Pick Best Organic Editor’s Pick Best Seller Best Natural Alternative Best THC-Free Best Customer Rated Best Starter Best Flavor Range

Compare the best CBD Oil for Alzheimer’s in 2021

Best CBD Oil for Alzheimer’s

1. Spruce 750mg Lab Grade CBD Oil
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Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
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The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD Helps with Alzheimer’s Disease

The suggested neuroprotective, anti-inflammatory, and antioxidant properties of cannabidiol (CBD), the non-psychoactive hemp derivative, have been explored and studied for their prospective benefits for Alzheimer’s disease (1) .

Alzheimer’s disease (AD) is the most common form of dementia that involves progressive and irreversible damage in memory and cognitive skills (2) .

The degenerative cause of Alzheimer’s disease is believed to start in the hippocampus region of the brain that is responsible for memory (3) .

  • Presence of beta-amyloid protein build-up (amyloid plaques)
  • A bnormal accumulation of tau protein (neurofibrillary tangles)
  • C hronic inflammation
  • H ardening of the arteries (atherosclerosis)
  • B eta-amyloid accumulation in the brain arteries

This disease disrupts neurons, resulting in apoptosis (cell death) and loss of neuron function (5) .

According to a clinical and scientific review of Alzheimer’s, the disease usually occurs in females over 65 (6) . The symptoms of Alzheimer’s comes in three stages: the early stage, middle stage, and late-stage (7) .

  • Memory loss
  • Mood and personality changes
  • Increased anxiety or aggression
  • Inability to learn new things
  • Problem recognizing family and friends
  • Hallucinations, paranoia, and delusions
  • Inability to communicate
  • Seizures
  • Increase sleeping
  • Loss of bladder and bowel control

It was reported in a study that endocannabinoids, particularly CBD, may play a vital role in the management of Alzheimer’s disease by offsetting the hyperactivity of amyloid-induced tau protein ’s inflammatory and neurochemical consequences (9) .

These amyloid-induced tau proteins may accumulate or form an abnormal aggregate that is said to cause Alzheimer’s (10) . Endocannabinoids are naturally occurring compounds that may be found in Cannabis sativa .

Another research on the potential functionality and role of the endocannabinoid system (ECS) in the treatment of Alzheimer’s disease reported that cannabinoids showed immunosuppressive effects and neuroprotective, anti-inflammatory, and antioxidant properties (11) .

The ECS is responsible for the different inflammatory and immune activities and other central nervous system functions (12) .

This neuromodulatory system has two primary receptors: the CB1 receptor, which regulates memory, motor control, and mood, and the CB2 receptor that is accountable for immunomodulatory functions (13) .

The psychological deficiencies of Alzheimer’s patients may be linked to the cerebral disturbances in the hippocampus and frontal cortex part of the brain that are known to be abundant in CB1 receptors (14) .

It was also noted that CB2 receptors in patients with Alzheimer’s were correlated with beta-amyloid plaques and levels (15) .

This receptor demonstrated the potential to assist in beta-amyloid processing and may prevent neuroinflammation in people with Alzheimer’s disease (16) .

Tetrahydrocannabinol (THC), the compound found in c annabis that has psychoactive effects, is shown to have a high affinity with the CB1 receptor (17) .

Although CBD alone binds weakly with CB1 and CB2 receptors, it was reported in a study that CBD is said to have the capability to antagonize these receptors in the presence of THC (18) .

A study also noted the neurogenesis and neuroinflammatory influences of the ECS on Alzheimer’s disease (19) .

It was reported that CBD has the potential to promote neurogenesis and lessen the production of the compressed fibrous neuroglia network (gliosis) (20) .

However, these promising benefits of cannabinoids in the pharmacology of Alzheimer’s disease requires further clinical trials.

Benefits of Using CBD Oil for Alzheimer’s Disease

CBD is known to have beneficial effects in psychiatric diseases, like depression, anxiety, and psychosis (21) .

A murine model of cerebral malaria showed that adjunct therapy using CBD improved the test subjects’ behavioral and cognitive functions (22) .

Several studies reported CBD’s possible neuroprotective, anti-inflammatory, and antioxidant properties (23) . The research discussed how CBD may help in the supplemental remedy of people who suffer from neurological disorders.

In in vitro (test tube experiment done in the laboratory) models of Alzheimer’s disease , researchers examined CBD’s protective role in synaptic plasticity. This ability is defined as the changes in synapses (junctions between neurons) , enabling neurons to communicate .

It was noted that CBD had protective properties against beta-amyloid peptide’s neurotoxic effects , resulting in neurodegeneration (24) .

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Neuroprotectant Properties

A study suggested that several cannabinoids showed possible neuroprotective effects by acting on the CB1 and CB2 receptors of the ECS (25) .

The neuroprotective properties of CBD were further investigated in a study showing how the treatment of cells with CBD greatly enhanced cell survival. The paper showed that CBD averted beta-amyloid-induced neurotoxicity.

Neuroprotective means the ability to protect brain cells and nerves from impairment and possible death (26) .

An animal study showed that CBD demonstrated neuroprotective activities in hypoxia-ischemia (HI)-induced (temporary occlusion of hypoxia and carotid arteries) newborn piglets (27) .

It was noted in the study that CBD had exhibited little to no adverse effects when administered.

Anti-inflammatory properties

Preclinical research on neurodegenerative disorders focused on the neuroprotective propert ies of CBD along with its antioxidant and anti-inflammatory effects (28) .

The researchers observed that CBD had anti-inflammatory properties beneficial for neuroinflammatory diseases , like multiple sclerosis (29) .

CBD’s anti-inflammatory effects were also associated with microglial cell migration, including the production of pro-inflammatory mediators targeting CB2 receptors (30) .

Antioxidant Properties

Individuals with A lzheimer’s disease exhibited high oxidative stress and damage connected with amyloid plaques and neurofibrillary tangles (31) .

A study mentioned that the antioxidant and anti-inflammatory properties of CBD had the potential to protect against oxidative stress and its resulting protein and lipid modification (32) .

Another study suggested that the combined use of CBD and THC demonstrated neuroprotective effects in animal models of Parkinson’s disease because of their antioxidant properties (33) .

CBD and Neurological Disorders

Alzheimer’s disease is said to comprise 60 to 70% of dementia cases (34) .

This condition is followed by other types of dementia , like vascular dementia (caused by impaired blood flow in the brain), Lewy bodies dementia (abnormal protein development in nerve cells), and frontotemporal dementia (deterioration of the brain’s frontal lobe).

The symptoms of dementia are similar to the symptoms of Alzheimer’s. Dementia also starts with memory loss or forgetfulness, behavior changes, and increasing difficulty in communication and walking (35) .

According to a study, conventional medications for treating Alzheimer’s disease offer limited therapeutic effects and are associated with adverse effects (36) .

Animal studies noted CBD’s effectiveness in treating acute seizures in mice and rat models (37) . Seizures are one of the prominent symptoms of Alzheimer’s.

Findings may support CBD’s promise as a potential alternative in helping patients manage Alzheimer’s disease symptoms . However, these studies are limited and inconclusive.

Other studies examined CBD’s beneficial effects on other neurological diseases . These conditions include Parkinson’s disease, a brain disorder that results in balance and coordination difficulties, stiffness, and shaking, and Huntington’s disease, a progressive brain impairment that causes changes in the central nervous area.

Similar to Alzheimer’s, both of these diseases cause memory loss and cognitive disabilities.

Eight patients with Parkinson’s disease were administered CBD a s a supplement to their usual therapy. Results showed that the rating scale in the psychosis questionnaire has significantly decreased (38) .

However, a controlled clinical trial of CBD for Huntington’s disease suggested that the administration of 700mg of CBD a day for six weeks did not show any beneficial or adverse effects to patients with the disease (39) .

How Soon Can CBD Oil be felt?

CBD oil, which is extracted from hemp, may be in the form of a tincture, vape pen cartridges, topicals, edibles, and patches (40) .

It is common practice to take CBD oil tinctures sublingually (41) . However, they may also be infused in edibles, like capsules and gummies, or applied topically.

Different forms of CBD oil also have various onset times . These types of CBD may be categorized by delivery systems or according to the routes in which they are taken (42) .

CBD administration routes include inhalation, sublingual absorption, ingestion, and transdermal and topical application (43) .

Sublingual Absorption

S ublingual delivery is when the CBD oil is dispensed under the tongue through a dropper and held for at least 90 seconds for the mouth’s mucous membrane to absorb the product (44) .

Through this method, CBD avoids passing through the stomach and liver and is diffused in the capillaries, eventually penetrating the bloodstream.

Taken sublingually, CBD’s bioavailability or absorption rate is at 6% to 20%. These figures are higher than the bioavailability of ingested CBD products (45) .

Moreover, CBD sublingual absorption has a 15 to 30-minute onset time . I ts effects may last from 4 to 6 hours.

Ingestion

Ingestion of CBD is the most common method of administering CBD oil (46) . This approach is also known as the “first-pass effect.”

In this route of delivery, CBD passes through the liver before being absorbed into the bloodstream.

Onset time ranges from 30 to 90 minutes, depending on your body’s metabolism. This period is relatively long compared to the onset time of other routes of administration (47) . However, the duration of the effects of CBD ingestion lasts the longest: 6 to 8 hours at most .

Edibles, including capsules, gummies, drinks, candies, and others , are the standard CBD products that may be administered through ingestion .

Inhalation

The delivery method that has the fastest onset time is the inhalation method through vaping and smoking (48) .

Inhalation has an onset time of 2 to 15 minutes before the user experiences CBD’s effects. This method allows CBD to be absorbed through the lungs and into the bloodstream.

Vaping or smoking has an absorption rate of 17% to 44%, and its effects may last for 2 to 4 hours (49) . However, according to the National Institute on Drug Abuse, some case studies reported that smoking marijuana may increase susceptibility to lung infections (50) .

Transdermal Absorption

CBD gels and patches use the transdermal absorption route. This method allows CBD to penetrate the dermis of the skin and go into the bloodstream (51) .

Transdermal CBD products have an onset time of 15 to 30 minutes and may last for 4 hours for gels and 8 hours for transdermal patches. T ransdermal patches are CBD-infused adhesive products that are normally applied to the wrist or ankle ( 52) .

Topical Absorption

Topical CBD products may be applied directly to the skin for more targeted relief (53) . These topicals are generally used to reduce skin inflammation, itchiness, or muscle pain.

This method does not pass through the bloodstream. Instead, it allows CBD to interact with the CB2 receptors of the skin (54) .

A 10 to 15 minutes onset time is expected when using CBD topicals. Its effects may last from 2 to 4 hours.

Risks of Using CBD for Alzheimer’s

A review on the safety and side effects of CBD reported that CBD generally has a safe and better side effect profile compared to other drugs (55) . However, treating Alzheimer’s with CBD needs to be handled with caution to avoid adverse effects and further damage to the quality of life of the patient.

Aside from CBD’s benefits, there are also known side effects that need to be considered before administering CBD to individuals with Alzheimer’s .

  • Dry mouth
  • Drowsiness
  • Fatigue
  • Diarrhea
  • Changes in appetite
  • Changes in weight
  • Nausea

Other risks of CBD include its possible drug-to- drug interactions. CBD may reduce or increase another drug’s effect (57) .

CBD may induce sleepiness and drowsiness (58) . Medications with similar effects should be taken with caution.

CBD and Its Legality

Industrial hemp is the derivative of Cannabis sativa with a low amount of THC and more abundant quantities of CBD. Under the 2018 Farm Bill, i t is federally legal to manufacture CBD-rich hemp products in the United States (59) .

However, the US Food and Drug Administration (US FDA) approved one CBD-infused drug for the treatment of childhood epilepsy only: Epidiolex . The medication aims to help treat rare forms of epilepsy, like Lennox-Gastaut syndrome and Dravet syndrome (60) .

CBD Dosage

There is no universally accepted and approved CBD dosage for wellness or possible treatment of a condition. You should consult a doctor to avoid overdose or unwanted drug-to-drug adverse effects.

For first – time users, it is advisable to start low and go slow when it comes to CBD. Starting with a low dosage of CBD may allow users to adjust their dose more efficiently and carefully.

Things to Consider When Buying CBD Products for Alzheimer’s

Type of CBD Extract

CBD and THC are found in the Cannabis plant. Their significant difference lies in their ability to induce euphoria.

CBD is the non-addictive and non-psychoactive cannabinoid normally found in hemp or cannabis strains that contain 0.3% THC. Contrastingly, THC is the psychoactive component of marijuana that has the ability to produce a high in users (61) .

CBD products are categorized into three types based on the content of the extract. Broad-spectrum CBD and CBD isolates do not have any traces of THC.

Moreover , broad-spectrum CBD has some cannabinoids present in the hemp plant ( except THC) , while CBD isolates have pure CBD only (62) .

Source of Hemp

Knowing the source of hemp oil or CBD extract used in a product, the quality of hemp, farming methods used, and the company’s protocols and regulations help when picking the right CBD product.

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Most CBD brands claim that they use organic, US-grown hemp. Oregon, Colorado, North Carolina, and Kentucky are a few states that are part of the hemp pilot program (64) .

Certificate of Analysis

It is a prudent choice to examine the certification of analysis (COA) of each CBD product before deciding to buy it.

The COA shows the information on the CBD concentration and potency of the product and the laboratory results for microbials, chemicals, solvents, and pesticides.

Amount of CBD Concentration and Potency

Extraction Method

The CBD extraction method is the process in which the hemp extract is obtained. It determines the purity and quality of the CBD extract.

Ingredients

It is best to check the CBD product’s ingredients to be aware of the possible allergic reaction s you may have to its components. This practice also avoids the occurrence of adverse effects upon CBD intake.

CBD products often contain carrier oils that may contribute to the beneficial effects of CBD. Two of the most common carrier oils are medium-chain triglyceride (MCT) coconut oil and hempseed oil.

Hempseed oil is known for being a source of healthy digestible proteins and dietary nutrients (67) . Moreover, MCT oil is commonly derived from coconuts and has omega-3 suitable for cardiovascular diseases (68) .

Product Frequently
Asked Questions

CBD binds with the endocannabinoid receptors that are found in the central nervous system. The brain tissues involved in Alzheimer’s are located in the brain’s hippocampus and frontal cortex, which have substantial amounts of the ECS’ CB1 receptors (69) .

Studies showed the neuroprotective properties of CBD that may be beneficial in the treatment of Alzheimer’s. It was also shown that CBD may have the ability to induce neurogenesis in Alzheimer’s disease (70) .

The limited amount of research studies on the effects of CBD on Alzheimer’s disease does present conclusive findings on whether CBD contributes to the worsening of the condition.

However, a physician’s advice is recommended before using any CBD products.

CBD may interact with medications that are similar to antidepressants, antihistamines, and opioids (71) . It is advisable to consult your doctor before taking any CBD products.

Due to CBD’s possible interaction with other medications, it is advisable to consult with a physician before taking any other treatment with CBD.

Due to the drow sy side effect of CBD, taking it with herbal supplements like catnip, California poppy, Jamaican dogwood, melatonin, sage, and skullcap may cause excessive sleepiness (72) .

If you take CBD alone or CBD with low THC doses, there are fewer chances of getting a positive drug test result . However, THC accumulated in the body may be detectable by drug tests .

There is no known dosage for CBD. However, starting on low doses and slowly increasing intake is advisable for first-time users.

CBD has anti-inflammatory, antioxidant, and neuroprotective properties that may be beneficial for people who have Alzheimer’s disease.

The effects of CBD depends on the route of administration and form of CBD product used. CBD may be taken sublingually, topically, transdermally. It may also be inhaled or ingested (73) .

Is cbd oil good for alzheimer’s disease

You may already know CBD has a wide range of therapeutic uses, but did you know its healing power is being considered as a potential drug to help treat and prevent Alzheimer’s and other neurodegenerative diseases?

It’s true. And the research is promising.

More than 5 million Americans are living with Alzheimer’s. It affects one in ten people over the age of 65. And one in three over the age of 85.

This progressive brain disease results in mental deterioration with symptoms that include confusion, memory loss, and trouble communicating.

But here’s the good news…

The pharmacologically active cannabis compound, cannabidiol (CBD) is showing great promise in its potential to prevent and slow this devastating disease.

And CBD is showing itself to be effective at treating some specific symptoms of Alzheimer’s as well.

We’ll discuss those in a minute.

While there is currently no known way to stop, reverse, or prevent Alzheimer’s, research is pushing forward at a frenzied pace, and exciting discoveries are being made all the time.

Which means:

We may soon find that CBD is an effective way to help treat and prevent Alzheimer’s.

What makes CBD such a good candidate for treating Alzheimer’s?

Our endocannabinoid system (ECS) regulates many of the physiological processes in our bodies but is mainly responsible for regulating our nervous system.

Patients with Alzheimer’s have an ECS that is disrupted by their disease. Fortunately, CBD and other cannabinoids have positive therapeutic effects on the ECS.

The major ways CBD has been shown to be beneficial for Alzheimer’s are —

  • Acting as a Neuroprotectant
  • Reducing Oxidative Stress Damage
  • Promoting Brain Cell Growth
  • Reducing Inflammation

Which is fueling hopeful research that…

CBD May Help Prevent Alzheimer’s

CBD Has Strong Neuroprotective Properties

The full extent of CBD’s neuroprotective properties are only beginning to be understood, and we won’t know for sure whether CBD is capable of preventing Alzheimer’s disease for some time.

But we do know for certain that CBD has beneficial effects on our brain. And the potential to be an effective prevention and treatment for Alzheimer’s certainly exists.

Here’s why the research is so exciting…

One of the key indicators of Alzheimer’s is its association with the buildup and clumping of a protein in the brain called amyloid. These clumps keep cells in the brain from receiving vital nutrients and important signals during synapsis and eventually cause the brain cells to die.

And CBD can help…

In a recent study published by the International Journal of Molecular Sciences, Italian researchers concluded that CBD could effectively inhibit the expression of the toxic precursor protein amyloid beta.

Their work demonstrated that when CBD is introduced as a pretreatment, it inhibits the production of genes that correlate to Alzheimer’s disease.

And a 2006 study conducted by a team of researchers at the University of Connecticut and published in Molecular Pharmaceutics, concluded that cannabis “could be considerably better at suppressing the abnormal clumping and malformed proteins that is the hallmark of Alzheimer’s disease than any currently approved prescription.”

At the time that research was conducted, the team predicted a near-future of cannabinoid-based medications to treat Alzheimer’s.

So is the future of CBD medicine for Alzheimer’s finally here?

CBD has great potential to play a key role in the development of treatments aimed at preventing Alzheimer’s.

And that’s not all. CBD is also showing the potential to treat Alzheimer’s as well.

CBD May Effectively Treat Alzheimer’s

While a lot of research is focused on understanding how CBD may be able to prevent Alzheimer’s, much more is focused on how CBD may be able to slow or stop existing conditions of patients who already have Alzheimer’s.
The enthusiasm for this research is grounded in CBD’s proven capability to heal and protect brain cells.

Here’s how the healing power of CBD may help treat Alzheimer’s…

Oxidative stress is related to a wide variety of diseases including Alzheimer’s. It is caused by oxygen being released in the brain’s cells as a reaction to the stress induced by the presence of the disease. As the oxidative stress increases, the disease progresses, and memory deteriorates. But with potent antioxidant properties, CBD has been shown to help reduce and repair oxidative stress, and improve brain function. Other antioxidants include vitamin C and vitamin E, but CBD is more powerful.

The brain cells of Alzheimer’s patients typically show rapid decline and deterioration. CBD has been shown to have the potential to stimulate brain tissue and promote the growth of brain cells. In clinical trials, CBD has demonstrated the ability to prevent and even reverse the negative impacts of Alzheimer’s – fueling the anticipation of further research and clinical trials.

Chronic inflammation is believed to be the root cause of many diseases. It is also the core cause of many symptoms experienced by Alzheimer’s patients. CBD has powerful anti-inflammatory properties that can be beneficial in reducing these symptoms.

And that’s not all CBD can do…
While Alzheimer’s is the largest subset of dementia, research suggests CBD may also be useful for treating other related forms of this neurodegenerative disease.

Dementia with Lewy Bodies

This is the second most common form of progressive dementia, immediately following Alzheimer’s. It is associated with the abnormal buildup of a protein called alpha-synuclein. The deposits of this protein are called Lewy bodies and they adversely affect the chemicals in our brain. This can lead to issues with mood, sleep, movement, behavior, and cognition. The problem with most medications prescribed to manage the pain, anxiety, and behavior issues associated with this disease, is that they also block acetylcholine – the primary brain chemical that this disease attacks. Meaning our current method of treating the symptoms of this disease have the potential to make the underlying problem worse. But – CBD is offering new hope. Unlike existing drugs on the market, CBD does not block acetylcholine and can also be used to help reduce tremors, sleep issues, and inflammation.

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Vascular Dementia

This form of dementia is caused by damage from impaired blood flow to the brain. It results in patients having a hard time with planning, judgment, reasoning, and memory. Research has shown that when CBD activates the CB2 receptors in our brain, it helps improve blood flow. The activated CB2 receptors can reduce associated brain cell damage.

Frontotemporal Dementia / Pick’s Disease

With this form of dementia, the brain’s frontal or temporal lobes are impaired by disorders that cause nerve cell loss. The symptoms of this disease include depression and psychosis. Again, CBD may prove to be more beneficial than the current antipsychotic medications which are associated with an increased risk of death. CBD has no such increased risk and has the potential to help reduce tremors, anxiety, and inflammation while improving sleep.

And here’s something else you should know…

Terpenes Have an Important Role, Too

What are terpenes?

Terpenes are the aromatic essential oils found in cannabis (and all other plants) that enhance its effects and therapeutic benefits. Terpenes also give cannabis flavor and aroma.

Like other cannabis compounds, terpenes are pharmacologically-active. More than 20,000 terpenes are present in nature.

Plants use terpenes to protect against herbivores and attract pollinators. Cannabis has naturally high concentrations, with about 100 known terpenes.

Terpenes powerfully affect the way cannabis reacts with our endocannabinoid system. This largely has to do with the synergistic relationship terpenes have with other cannabis compounds.

In this relationship, the therapeutic benefits of terpenes are enhanced in a phenomenon known as the entourage effect.

Here are some of the terpenes that hold the greatest promise for Alzheimer’s and dementia patients —

Expect an earthy, sweet scent from this terpene that can also be found in many culinary plants like rosemary, basil, and peppers. You’ll also find it in cedar, pine, and fir. Carene can help repair bones – particularly if damaged by malnutrition. It is also known to stimulate memory and retention, causing it to be of significant interest to cognitive research.

Eucalyptol is the primary terpene in eucalyptus trees. It is also found in rosemary, bay, and sage. Its signature pungent scent is very popular in aromatherapy and widely used in healing centers. Its cooling effect has been shown to ease pain, stress, and tension, and reduce blood pressure. Eucalyptol has antibacterial and anti-inflammatory properties and is showing promise as a topical treatment for peripheral neuropathy patients. It may also prove to help slow cognitive function decline triggered by neurodegenerative diseases like Alzheimer’s.

This terpene is the most present in the flowers of geraniums and gives them their sweet, delicate scent. It is also found in many foods like lemons, coriander, and blueberries, to name a few. It is a regular ingredient in items produced by the food and cosmetic industries, where it is used to develop sweet, fruity scents and flavors. It is also produced in the scent glands of honeybees and helps them track and navigate their way to-and-from nectar-producing plants and their hive. As a therapeutic treatment, a recent study has demonstrated that geraniol can delay some symptoms of Alzheimer’s.

Commonly used as an ingredient in household cleaners, cosmetics, and aromatherapy products, Linalool is a natural oil found in lavender, cinnamon, mint, citrus fruits, and much more. It is a powerful relaxant and promotes sleep. It has been found to be helpful in calming agitation that Alzheimer’s patients often experience.

This terpene, like the others, is found in many plants in nature. Some of those plants include pine nuts, sage, parsley, dill, and juniper berries. It has a strong pine scent and is often used in small amounts as an ingredient in food, cosmetics, and household cleaners. Its primary benefit to Alzheimer’s patients is its capability to inhibit the breakdown of acetylcholine, which plays a major role in memory function.

Common in both citrus and cannabis, limonene is often used as an ingredient in foods and beverages where it lends a tart, sour, fresh flavor. It is also used as an antidepressant and immune booster, which is how it may benefit Alzheimer’s patients.

And perhaps most interestingly…

This terpene has the distinction of also being a cannabinoid – and it may be the most important terpene relative to treating Alzheimer’s. It is also found in cloves, hops, rosemary, and other common plants. What makes it such a good candidate for treating Alzheimer’s is its ability to help clear the toxic precursor protein amyloid beta from the brain.

The synergy between cannabis compounds like CBD and terpenes is advancing the idea that treatments which combine different compounds may be more effective than ones that are based on CBD as an isolate.

But as mentioned earlier, there are some Alzheimer’s symptoms that CBD alone has demonstrated its potential to treat effectively.

And those specific symptoms CBD has the potential to treat are…

CBD May Effectively Treat Symptoms of Alzheimer’s

In studies, CBD is showing promise in not only having the potential to slow or possibly stop the progression of the disease but also to treat some of the associated symptoms.

These specific symptoms include —

  • Sleeplessness
    Sleeplessness does not typically last through all stages. It usually occurs at the peak stage of Alzheimer’s. CBD has known sedative effects that promote sleep.
  • Agitation and Aggression
    Often, Alzheimer’s patients will experience increased confusion, anxiety, and agitation that starts late in the day. This is common in moderate to severe stages of the disease. CBD can ease anxiety and help manage aggression.
  • Loss of Appetite
    As Alzheimer’s progresses, patients typically experience a loss of appetite and begin to lose weight. CBD naturally promotes appetite and can be helpful in combating unhealthy weight loss.
  • Seizures
    Severe cases of Alzheimer’s can include seizures. CBD has been shown to be effective in reducing seizures in epilepsy patients. All indications are that it has the potential to do the same for patients suffering from episodes of dementia-related seizures.
  • Depression
    During the early and middle stages of Alzheimer’s, it is very common for patients to fall into a state of depression. CBD protects neurons in the hippocampus – which is the area of the brain that becomes atrophied during depression. But the hippocampus is resilient and CBD has been proven to be an effective treatment for helping it recover by reducing neuron atrophy.
  • Skin Infections
    Patients with Alzheimer’s are prone to various infections that may result in uncomfortable, itchy skin. CBD can relieve the symptoms of many common skin conditions.

The Future of CBD Treatments for Alzheimer’s

Laboratory research has been critical for establishing a foundation for more in-depth a investigation to move research forward, and now clinical trials of CBD as a treatment for Alzheimer’s are on the horizon.

In the U.K., Alzheimer’s patients are beginning clinical trials of Sativex,® a cannabis-based drug. Administered as a peppermint-flavored mouth spray, it contains both CBD and THC compounds.

Patients in the trial are between the ages of 55-90. Researchers hope the treatment will show promise for alleviating the common symptoms of aggression and agitation.

Previous studies of the drug were conducted with people who have Multiple Sclerosis, and those studies yielded some promising results, leading Sativex,® to be approved for some MS patients.

Research in the US has been slower to move forward, primarily because of the difficulties surrounding the federal status of cannabis and the legal requirements imposed for studies to be conducted.

It is expected that US research will move forward more rapidly as scientists around the world begin to uncover new revelations about the therapeutic potential of CBD and other cannabis compounds.

Here is the key take away –

We don’t yet have the answers for how to prevent and cure Alzheimer’s disease, but the proven therapeutic benefits of CBD are driving research to find better treatment solutions.

And this exciting area of research has ignited new hope that safer, more effective medication options for Alzheimer’s patients will soon be available.

In the meantime…

Experience CBD’s Other Benefits

Of course, CBD has been used effectively to treat a wide range of issues other than Alzheimer’s. And you can experience those therapeutic benefits.
CBD comes in a variety of consumables, sprays, and topicals, but perhaps the easiest way to get started is with CBD oil. Some products contain an isolate, and some contain a full spectrum of cannabinoids.

Due to the synergistic nature of the compounds present in cannabis and the enhanced benefits produced by their interaction, full-spectrum oils are generally recommended.

Want to try CBD Oil for yourself?

With so many choices now available, it can be overwhelming to get started. But we’ve got you covered. Check out our Definitive Buyer’s Guide to Full-Spectrum CBD Oil.

It will cover everything you need to know to feel confident in making your first purchase.

Browse Our Best CBD Oil For Preventive Senior Care Below